Intracellular Tumor-Associated Antigens Represent Effective Targets for Passive Immunotherapy
نویسندگان
چکیده
منابع مشابه
Intracellular tumor-associated antigens represent effective targets for passive immunotherapy.
Monoclonal antibody (mAb) therapy against tumor antigens expressed on the tumor surface is associated with clinical benefit. However, many tumor antigens are intracellular molecules that generally would not be considered suitable targets for mAb therapy. In this study, we provide evidence challenging this view through an investigation of the efficacy of mAb directed against NY-ESO-1, a widely e...
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Monoclonal antibody (mAb) therapy against tumor antigens expressed on the tumor surface is associated with clinical benefit. However,many tumor antigens are intracellularmolecules that generallywould not be considered suitable targets formAb therapy. In this study, we provide evidence challenging this view through an investigation of the efficacy of mAb directed against NY-ESO-1, a widely expre...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2012
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-11-3072